![]() If metastasis of cancer cells occurs before clinical detection, surgical resection may not prevent recurrence, invasion, and further metastasis. Metastasis of malignant tumors can occur at an early stage of primary tumorigenesis. Metastasis is mostly driven by the acquisition of genetic and/or epigenetic alterations within tumor cells and the formation of the tumor microenvironment. Although considered a “localized tumor”, gastric cancer may show locoregional metastasis and this can be the most important signal of negative prognosis. The five-year cumulative risk of relapse (restricted to patients who undergo R0 resections and excluding in-hospital deaths) for patients with pathological stage T3 tumors is 83% for D1 dissection and 72% for D2 dissection. Therefore, there is a lack of information regarding specific distant metastasis sites. Currently, the TNM system is used to stage malignant tumors, and cancer registries often only use “M0” and “M1” to indicate the absence or presence of distant metastasis. We report the case to promote the exploration and monitoring of unusual rare metastatic sites of advanced gastric cancer, and provide clinical evidence for the diagnosis and treatment of metastasis of gastric cancer.Įpidemiological studies on metastasis of gastric cancer are rare. However, left armpit subcutaneous metastasis occurred in the fifth year after surgery. Here we report the case of a patient with stage III gastric carcinoma who underwent curative intent resection (R0) and D2 lymph node dissection and received eight cycles of chemotherapy post-surgery. Today, there is no data referring to the left armpit metastasis of gastric carcinoma. The most common metastasis sites of gastric carcinoma are the liver (48%), peritoneum (32%), lung (15%), and bone (12%) however, relevant data indicated that the incidence of subcutaneous metastasis of gastric cancer is about 0.8%. According to the Eindhoven Cancer Registry statistics, between 19, about 40% of gastric cancer patients had one metastasis at least. The highest incidence is observed in Eastern Asia. Gastric cancer is prevalent worldwide, with an average of approximately 990000 new cases per year from 182 countries and 30 world regions. ![]()
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